Gout is a painful and debilitating condition that affects millions of people worldwide. This condition is caused by high levels of uric acid in the blood, which can lead to the formation of uric acid crystals in the joints, causing inflammation and intense pain. While genetics can play a role in the development of gout, lifestyle factors can also worsen the pain associated with the condition.
In this blog post, we’ll take a closer look at how genetics can drive gout in families, and explore the lifestyle factors that can make gout pain worse.
Genetics and Gout
It is well established that genetics can play a significant role in the development of gout. Studies have shown that people with a family history of gout are at a higher risk of developing the condition themselves. In fact, according to the Arthritis Foundation, a family history of gout is one of the strongest risk factors for the condition.
The reason for this is that certain genetic mutations can affect the way the body processes uric acid. For example, mutations in the SLC2A9 gene, which is responsible for transporting uric acid out of the body, can lead to higher levels of uric acid in the blood, increasing the risk of gout.
Other genetic factors that have been linked to gout include mutations in the ABCG2 gene, which plays a role in the transport of uric acid in the kidneys, and mutations in the PRKG2 gene, which is involved in regulating the production of uric acid.
While genetics can certainly increase the risk of developing gout, it’s worth noting that not everyone with a family history of the condition will develop it. Lifestyle factors also play a significant role in the development and progression of gout.
Lifestyle Factors and Gout Pain
If you have gout, or are at risk of developing the condition, there are several lifestyle factors that can worsen your symptoms. These include:
- Diet: Certain foods are known to trigger gout attacks, including red meat, organ meats, shellfish, and sugary drinks. These foods are high in purines, which the body breaks down into uric acid. Eating a diet that is high in purines can increase the levels of uric acid in the blood, leading to gout attacks.
- Alcohol: Drinking alcohol, particularly beer and hard liquor, can also trigger gout attacks. Alcohol can interfere with the body’s ability to excrete uric acid, leading to higher levels of uric acid in the blood.
- Obesity: Being overweight or obese is another risk factor for gout. People who are overweight or obese are more likely to have higher levels of uric acid in their blood, increasing their risk of developing gout.
- Inactivity: A sedentary lifestyle can also worsen gout symptoms. Exercise can help to lower uric acid levels in the blood and improve joint health.
- Medications: Certain medications, such as diuretics and aspirin, can also increase the risk of gout attacks.
Managing Gout with Lifestyle Changes
While genetics can increase the risk of developing gout, lifestyle factors play a significant role in the management of the condition. Making lifestyle changes can help to reduce the frequency and severity of gout attacks.
One of the most important lifestyle changes you can make is to modify your diet. Eating a diet that is low in purines and high in fruits, vegetables, and whole grains can help to reduce uric acid levels in the blood and prevent gout attacks. Foods that are particularly beneficial for gout include low-fat dairy products, cherries, and foods that are high in vitamin C.
Reducing alcohol consumption, losing weight if you’re overweight, and getting regular exercise can also help to manage gout symptoms